Using theophylline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Such preparations, often with a mild sedative added, dominated the market for oral. Theophylline in dextrose theophylline injection, solution. This drug is given in divided doses every 46 hours.
Smoking cigarettes or other tobacco products may markedly influence the effects of theophylline. Calculate initial dosage using the following equation. Aminophylline and theophylline are medicines used to treat lung diseases such as asthma. Because of differences in theophylline clearance, the dose needed to achieve a peak theophylline of 10 to 20 mcgml varies up to fourfold e. Theophylline is an oral medication used to treat asthma and other lung diseases. Learn who its for, how it works, its side effects, warnings, and more.
If patient is already taking theophylline, give smaller loading dose. Optimizing the dosing of intravenous theophylline in acute severe. Jun 10, 2015 chronic obstructive pulmonary disease copd is associated with high morbidity, mortality, and healthcare costs. Doses should be individualized based on steadystate serum concentrations and ideal body weight. Theophylline toxicity signs, symptoms, treatment, amount. Theophylline does not undergo any appreciable presystemic elimination, distributes freely into fatfree tissues, and is extensively metabolized in the liver. Remove immediately before administration and squeeze bag to checkforleaks. Find patient medical information for theophylline oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. See what others have said about theophylline, including the effectiveness, ease of use and side effects.
Webmd provides common contraindications for theophyllineguaifenesin oral. Theophylline in dextrose theophylline injection, solution hospira, inc. Your dose will be adjusted based on the amount of theophylline in the blood. Theo 24, theocron theophylline dosing, indications. Aminophylline loading doses determined from these values more frequently resulted in drug concentrations in the therapeutic range 10. Some other theophylline warnings and precautions to be aware of include the safety of taking theophylline while pregnant, the risk of a very high fever in some people taking the drug, and people who shouldnt take it at all such as those who are allergic to theophylline or any component used to make it. If iv aminophylline is changed to oral theophylline, then the total daily dose of iv aminophylline should be multiplied by 0. Side effects, uses, dosage tablets, warnings, benefits, precautions, mechanism of. When converting from iv to oral therapy, it may not be possible to exactly match the. Theophylline complete drug information, side effects and.
Theophylline intravenous route description and brand. Theophylline is rapidly and completely absorbed after oral administration in solution or immediaterelease solid oral dosage form. The drug theophylline is used as a treatment for several respiratory conditions. Child dosage babies born at fullterm up to 12 months of age. Antiinflammatory dosing of theophylline in the treatment of.
Comparison of intravenous and oral routes of theophylline. A calculator used to determine the appropriate dosage of theophylline. Theophylline belongs to a group of medicines known as bronchodilators. A single 5 mgkg dose produces and average peak serum theophylline concentration of 10 mcgml range 5 to 15 mcgml inhaled beta2 agonists, alone or combined with a systemic. Like any other drugs, theophylline must be taken in its recommended dosage. Theophylline, despite its adverse effects and narrow therapeutic range, as discussed above, is still a potent bronchodilator. Feb 18, 2016 theophylline is rapidly and completely absorbed after oral administration in solution or immediaterelease solid oral dosage form. Preclinical work indicates that low dose theophylline improves steroid responsiveness.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Theophylline is an effective, easytouse prescription bronchodilator for use in the treatment of various airway constrictions, including asthma, allergies, and other pulmonary disorders. Iv theophylline in 5% dextrose are packed ina moisturebarrier overwrap. Do not administer intravenous aminophylline too rapidly as it can cause anxiety. In most adult patients receiving intravenous aminophylline, a sustainedrelease theophylline product administered every 12 hours is selected when oral therapy is initiated. Positive 251 so now im on the theophylline and it iswas working fine, but since we are moving we are trying trying being the key word lol to get the house looking good so nana went out and got a new carpet for the living room and dinning room where the puter is too and i helped my uncle move everything out and put the carpet down and then move everything back and i have been sneezing. Theophylline intravenous advanced patient information. Dailymed theophylline anhydrous theophylline tablet. Theophylline works to clear passages to your pets lungs and keep them healthy. Theophylline anhydrous theophylline tablet, extended. What is theophylline side effects, dosage, mechanism of.
Theophylline 200, 400 and 800 mg in 5% dextrose injection, usp. The combination of theophylline and ephedrine was described in a 1940 publication 2. Your theophylline dosage is prescribed based on factors like the specific form of theophylline and your age. Theophylline does not undergo any appreciable presystemic elimination, distributes freely into fatfree tissues and is extensively metabolized in the liver.
It occurs as a white, odorless, crystalline powder with a bitter taste. Theophylline comes as an extendedrelease longacting tablet, extendedrelease capsule, and a solution liquid to take by mouth. Theophylline is an example of a xanthine derivative that stimulates the beta receptors of the body. Theophylline was first identified as having potential for asthma as a bronchodilator in 1921 and 1922 1, but general use as a bronchodilator was not seen until the 1930s. Theophylline in 5% dextrose theophylline dose, indications. Theo 24, theocron theophylline dosing, indications, interactions. Notify your health care provider if you change your smoking habits while you are taking this drug. It is preferable not to smoke while you are taking this drug. The theophylline with inhaled corticosteroids twics trial investigates whether the. See what others have said about theophylline, including. They help prevent and treat wheezing and other breathing problems, including respiratory distress associated with premature birth. What you need to know about using serevent diskus april 3, 2018. Use of lowdose oral theophylline as an adjunct to inhaled. Theophylline 5% dextrose injection excel theophylline in.
Therapeutic effect and dosing strategies for theophylline in. Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines. Theophylline elixophyllin, theo24 daviss drug guide. Alternatively, multiply the hourly aminophylline dose by 10, to obtain the theophylline dose to be given every 12 hours. Intravenous aminophylline should be reserved for the few. Current research regarding theophylline based therapies are oriented towards employing theophylline, as well as other methylxanthines as natural scaffolding for new bronchodilatory pharmaceuticals. If used together, your doctor may change the dose or how often you use theophylline, or give you special instructions about the use of food, alcohol, or tobacco. Flexible plastic container do not admix with other drugs rx only description theophylline is structurally classified as a methylxanthine. Apr 01, 2019 theophylline injection is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases in a hospital setting. Oct 18, 2012 how to build a hinged hoophouse for a raised bed garden duration.
The gardening channel with james prigioni recommended for you. V patients not currently receiving aminophylline or theophylline. According to the centers for disease control, one in americans suffer from asthma. By continuing to browse this site you are agreeing to our use of cookies.
In children 115 years of age, the final theophylline dose should not exceed 16 mgkgday up to a maximum of 400 mgday in the presence of risk factors for reduced theophylline clearance see warnings or if it is not feasible to monitor serum theophylline concentrations. Use cautiously in young children, infants, neonates, and elderly patients. Find out what health conditions may be a health risk when taken with theophyllineguaifenesin oral. If patient has had another form of theophylline before loading dose, obtain serum theophylline level and reduce. Obtain a second serum theophylline concentration about one halflife after starting the infusion. Bronchodilators are medicines that relax the muscles in the bronchial tubes air passages of the lungs. Acute bronchospasm in patients not receiving theophylline. An incomplete response to the antiinflammatory effects of inhaled corticosteroids is present in copd. Because of marked individual differences in the rate of theophylline clearance, the dose required to achieve a peak serum theophylline concentration in the 10 20 mcgml range varies fourfold among otherwise similar patients in the absence of factors known to alter theophylline clearance e. Once a serum concentration of 10 to 15 mcgml theophylline is achieved by loading dose.
Increases in the dose of intravenous theophylline should not be made in response to an acute exacerbation of symptoms unless the steady. Of these individuals, 65% have whats called persistent asthma. Measuring theophylline levels the therapeutic range for theophylline is. Theophylline intravenous prescription drug information.
Simple conversion from intravenous aminophylline to twice. Youve read meteringcount of meteringtotal articles this month. A toxic dose of this drug may lead to a condition known as theophylline toxicity 1, 2. Theophylline elixophyllin, theo24 is a bronchodilator prescribed for the treatment of asthma and other airway conditions. Incorporation of this variable in the multivariable models had no impact on parameter. Theophylline definition of theophylline by medical dictionary. People in this group need to take asthma medications longterm.
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